Intralesional Cryosurgery to Treat Keloid Scars: Results from a Retrospective Study

Marianne Chopinaud a Anne-Dominique Pham b Daniel Labbé c
Laurence Verneuil a Charlotte Gourio d Hervé Bénateau c Anne Dompmartin a
Departments of a Dermatology, b Biostatistics and Clinical Research, c Maxillo-Facial and Plastic Surgery and
d Biology and Pharmacy, Caen University Hospital, Caen , France

Key Words
Keloid scars · Cryosurgery · Intralesional cryosurgery
Abstract
Background: A variety of treatment modalities have been
proposed to treat keloid scars, but outcomes are often disappointing.
Intralesional cryosurgery may significantly reduce
these scars. Objective: To evaluate the clinical safety
and efficacy of intralesional cryosurgery to treat keloid scars.
Feedback from patients on pain, pruritus and aesthetic discomfort
was recorded before and after treatment. Methods:
A total of 10 patients with 14 keloid scars resistant to conventional
treatments were enrolled in a retrospective study between
October 2007 and October 2013. The efficacy of this
treatment was evaluated by measuring the reduction in scar
surface. Results: Scar surface was reduced by an average
of 58.5% after intralesional cryosurgery treatment for all
scars (average pre-operative keloid scar surface: 874.6 ±
954.1 mm 2 ; average post-operative keloid scar surface: 505.8
± 1,024.7 mm 2 ; p = 0.002). Pain and aesthetic discomfort
were significantly decreased after treatment in all patients
(p = 0.008 and p = 0.012, respectively). Conclusion: Our data
suggest that intralesional cryosurgery is an effective treatment
for keloids.